Protein Details: ATP-sensitive inward rectifier potassium channel 12

Protein ID

ICDB_Pro_0125

Protein Name

ATP-sensitive inward rectifier potassium channel 12

Gene Name

KCNJ12

Organism

Gallus gallus (Chicken)

Length

429 amino acids

AlphaFoldDB

AF-F1NHE9-F1-model_v4.pdb

Function

Inward rectifying potassium channel that is activated by phosphatidylinositol 4;5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions

Sequence

MTAGRVNPYSIVSSEEDGLRLTTMPGINGFGNGKIHTRRKCRNRFVKKNGQCNVEFTNMDDKPQRYIADMFTTCVDIRWRYMLLLFSLAFLVSWLLFGLIFWLIALIHGDLENPGGDDTFKPCVLQVNGFVAAFLFSIETQTTIGYGFRCVTEECPLAVFMVVVQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVAMRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRITEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEINEDSPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVLFEEKNQYKVDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSTNSFCYENELAFMSRDEDEEDDDSRGLDDLSPDNRHEFDRLQATIALDQRSYRRESEI

PDB Structures

3JYC 3SPC 3SPG 3SPH 3SPI 3SPJ 5KUK 5KUM 6M84 6M85 6M86

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature03154; 10.1126/science.1180310; 10.1038/nature10370

RefSeq

XP_004945226.1; XP_004945227.1; XP_015149865.1